Infertility affects approximately 13-18% couples of child bearing age. Male infertility accounts for approximately half of these cases. Male infertility is known to have a genetic basis in many cases. 17% of azoospermic/oligospermic males are karyotypically abnormal. The associated genetic changes includes, aneuplodies, structural aberrations (deletions, translocations, inversions) and gene mutations (CFTR mutations in obstructive azoospermia). Deletions in Azoospermic regions (AZFa, AZFb and AZFc) on Y-chromosome have been shown to be associated with infertility.

 

The aim of this work was to

1. find out the cytogenetic and molecular basis of male infertility.